| 货号 | 21716-25mg |
| 描述 | Mycophenolic Acid is an immunosuppressive natural product that inhibits inosine monophosphate dehydrogenase (IC50 = 11 nM; Ki = 30-45 nM).1,2,3 Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation.3 It has antifungal, antibacterial, antitumor, and antiviral properties.4,5,6 Mycophenolic acid, typically used in clinical settings as a chemotherapeutic or immunosuppressant agent, is rapidly conjugated on absorption and circulates mostly in the form of its glucuronide conjugate.3,7,8 |
| 别名 | MPA;NSC 129185; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mitsui, A. and Suzuki, S. Immunosuppressive effect of mycophenolic acid. J. Antibiot. (Tokyo) 22(8), 358-363 (1969). 2.Franklin, T.J. and Cook, J.M. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem J. 113(3), 515-524 (1969). 3.Watkins, W.J.,Chen, J.M.,Cho, A., et al. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorganic & Medicinal Chemistry Letters 16(13), 3479-3483 (2006). 4.WIlliams, R.H.,Lively, D.H.,DeLong, D.C., et al. Mycophenolic acid: Antiviral and antitumor properties. J. Antibiot. (Tokyo) 21(7), (1968). 5.Abraham, E.P. The effect of mycophenolic acid on the growth of Staphylococcus aureus in heart broth. Biochem J. 39(5), 398-408 (1945). 6.Noto, T.,Sawada, M.,Ando, K., et al. Some biological properties of mycophenolic acid. J. Antibiot. (Tokyo) 22(4), 165-169 (1969). 7.Encke, J.,Uhl, W.,Stremmel, W., et al. Immunosuppression and modulation in liver transplantation. Nephrology Dialysis Transplantation 19(Suppl. 4), iv22-iv25 (2004). 8.Knoop, C.,Haverich, A. and Fischer, S. Immunosuppressive therapy after human lung transplantation. European Respiratory Journal 23, 159-171 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 320.3 |
| 分子式 | C17H20O6 |
| CAS号 | 24280-93-1 |
| 稳定性 | ≥ 2 years |
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