| 货号 | 21607-10mg |
| 描述 | Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.1 In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.2 It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.3,4,5 Benidipine is also a competitive antagonist at mineralocorticoid receptors.1 |
| 别名 | (±)-Benidipine;KW-3049; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kosaka, H.,Hirayama, K.,Yoda, N., et al. The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur. J. Pharmacol. 635(1-3), 49-55 (2010). 2.Yamamoto, M.,Gotoh, Y.,Imaizumi, Y., et al. Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells. Br. J. Pharmacol. 100(4), 669-676 (1990). 3.Karasawa, A.,Kubo, K.,Shuto, K., et al. Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in rats. Arzneimittel-Forschung 38(11A), 1684-1690 (1988). 4.Matsubara, M.,Akizuki, O.,Ikeda, J., et al. Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rat. Eur. J. Pharmacol. 580(1-2), 201-213 (2008). 5.Choi, N.-Y.,Choi, H.,Park, H.-H., et al. Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells. Brain Res. 1551, 1-12 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 542 |
| 分子式 | C28H31N3O6 • HCl |
| CAS号 | 91599-74-5 |
| 稳定性 | ≥ 2 years |
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