Reparixin (L-Lysine salt)
货号：
21492-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 21492-1mg |
| 描述 | Reparixin is a non-competitive allosteric inhibitor of the activation of CXCR1 and CXCR2 chemokine receptors by IL-8 (IC50s = 1 and 100 nM, respectively).1 It blocks a range of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists.1 In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks reduces blood pressure by inhibiting hypertension-related mediators, IL-8, 12-lipoxygenase, and endothelin-1.2 Reparixin blockade (100 nM) of CXCR1 depletes a cancer stem cell population in human breast cancer cell lines in vitro.3 |
| 别名 | Repertaxin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bertini, R.,Allegretti, M.,Bizzarri, C., et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury. Proc.Nat.Acad.Sci.USA 101(32), 11791-11796 (2004).
2.Kim, H.Y.,Choi, J.H.,Kang, Y.J., et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol. Pharm. Bull. 34(1), 120-127 (2011).
3.Ginestier, C.,Liu, S.,Diebel, M.E., et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. Journal of Clinical Investigation 120(2), 485-497 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 429.6 |
| 分子式 | C14H21NO3S • C6H14N2O2 |
| CAS号 | 266359-93-7 |
| 稳定性 | ≥ 2 years |
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