Sulfadoxin
货号：
21488-5g 基本售价：
406.0 元 规格：
5 g
产品信息
概述| 货号 | 21488-5g |
| 描述 | Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid (Item No. 20515) synthesis.1 Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid.2 Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum.2,3 Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/mL) and resistant strains (IC50 = 3,970 ng/mL).3 |
| 别名 | Ro 4-4393; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brooks, D.R.,Wang, P.,Read, M., et al. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem. 224(2), 397-405 (1994).
2.Hyde, J.E. Exploring the folate pathway in Plasmodium falciparum. Acta. Trop. 94(3), 191-206 (2005).
3.Wang, P.,Read, M.,Sims, P.F.G., et al. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.. Mol. Microbiol. 23(5), 979-986 (1997).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 310.3 |
| 分子式 | C12H14N4O4S |
| CAS号 | 2447-57-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
