Avitinib
货号：
21387-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 21387-1mg |
| 描述 | Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR.1 In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.1 |
| 别名 | AC0010; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xu, X.,Mao, L.,Xu, W., et al. AC0010, an irreversible EGFR inhibitor selectively targeting mutated EGFR and overcoming T790M-induced resistance in animal models and lung cancer patients. Mol. Cancer Ther. 15(11), 2586-2597 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 487.5 |
| 分子式 | C26H26FN7O2 |
| CAS号 | 1557267-42-1 |
| 稳定性 | ≥ 2 years |
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