PT1
货号：
21335-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 21335-1mg |
| 描述 | PT1 is an activator of AMP-activated protein kinase (AMPK) that directly activates the inactive truncated forms of AMPK monomers α1335, α1394, and α2398 in a dose-dependent manner (EC50s = ~ 8, 8, and 12 µM, respectively).1 It stimulates the α1β1γ1 AMPK heterotrimer with an EC50 value of 0.3 μM.1 PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes.1 In HepG2 liver cells, PT1 lowers lipid content through AMPK activation.{Pan} PT1 induces autophagy in cardiomyocytes after oxygen glucose deprivation/reoxygenation, resulting in improved cell survival.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pang, T.,Zhang, Z.-S.,Gu, M., et al. Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J. Biol. Chem. 283(23), 16051-16060 (2008).
2.Huang, L.,Dai, K.H.,Chen, M., et al. The AMPK agonist PT1 and mTOR inhibitor 3HOI-BA-01 protect cardiomyocytes after ischemia through induction of autophagy. J. Cardiovasc. Pharmacol. Ther. 21(1), 70-81 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 497.9 |
| 分子式 | C23H16ClN3O6S |
| CAS号 | 331002-70-1 |
| 稳定性 | ≥ 2 years |
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