| 货号 | 21206-500ug |
| 描述 | L-858,051 is a water-soluble analog of forskolin (Item No. 11018), a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 µM), inhibits glucose transport, and blocks cytochalasin B (Item No. 11328) binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Laurenza, A.,Khandelwal, Y.,De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin. Mol. Pharmacol. 32(1), 133-139 (1987). 2.Joost, H.G.,Habberfield, A.D.,Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action. Mol. Pharmacol. 33(4), 449-453 (1988). 3.Funaki, C.,Hodges, R.R. and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am. J. Physiol. Cell Physiol. 293(5), C1551-C1560 (2007). 4.Luo, S.-F.,Chiu, C.-T.,Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells. Cell. Signal. 9(2), 159-167 (1997). 5.Haj Slimane, Z.,Bedioune, I.,Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc. Res. 102(1), 97-106 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 609.6 |
| 分子式 | C29H50N2O8 • 2HCl |
| CAS号 | 115116-37-5 |
| 稳定性 | ≥ 2 years |
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