| 货号 | 21182-1mg |
| 描述 | DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC50 = 0.13 µM).1 It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively).1 DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.2,3,4 |
| 别名 | Casein Kinase II Inhibitor II;2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pagano, M.A.,Bain, J.,Kazimierczuk, Z., et al. The selectivity of inhibitors of protein kinase CK2: An update. Biochem. J. 415(3), 353-365 (2008). 2.Lawnicka, H.,Kowalewicz-Kulbat, M.,Sicinska, P., et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 340(2), 371-379 (2010). 3.Sass, G.,Klinger, N.,Surma, H., et al. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int. J. Oncol. 39(2), 433-442 (2011). 4.Yde, C.W.,Frogne, T.,Lykkesfeldt, A.E., et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 256(2), 229-237 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 476.8 |
| 分子式 | C9H7Br4N3 |
| CAS号 | 749234-11-5 |
| 稳定性 | ≥ 2 years |
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