| 货号 | 21164-1mg |
| 描述 | Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 µM) and suppressing the proliferation of T cells.1 Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis.1,2,3 Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 µg/ml, respectively) through cell cycle arrest and apoptosis.4 |
| 别名 | Cambogin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cen, J.,Shi, M.,Yang, Y., et al. Isogarcinol is a new immunosuppressant. PLoS One 8(6), e66503 (2013). 2.Fu, Y.,Zhou, H.,Wang, M., et al. Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana L. against collagen-induced arthritis. J. Agric. Food Chem. 62(18), 4127-4134 (2014). 3.Wang, M.,Xie, Y.,Xhong, Y., et al. Amelioration of experimental autoimmune encephalomyelitis by isogarcinol extracted from Garcinia mangostana L. Mangosteen.. J. Agric. Food Chem. 64(47), 9012-9021 (2016). 4.Pieme, C.A.,Ambassa, P.,Yankep, E., et al. Epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia induce apoptosis of human promyelocytic leukemia (HL-60 cells). BMC Res. Notes 8, 700 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 602.8 |
| 分子式 | C38H50O6 |
| CAS号 | 71117-97-0 |
| 稳定性 | ≥ 2 years |
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