| 货号 | 21047-5mg |
| 描述 | Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniaeandM. tuberculosis(MIC50s = 0.25 and 8 µg/ml, respectively).1,2 Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases.3,4 Formulations containing gemifloxacin are useful against respiratory tract infections, particularly community-acquired pneumonia and tuberculosis.1,5,6 |
| 别名 | LB 20304a;SB 265805S; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hammerschlag, M.R.,Roblin, P.M. and Bébéar, C.M. Activity of telithromycin, a new ketolide antibacterial, against atypical and intracellular respiratory tract pathogens. J. Antimicrob. Chemother. 48(Topic T1), 25-31 (2001). 2.Ruiz-Serrano, M.J.,Alcalá, L.,Martínez, L., et al. In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs. Antimicrob. Agents Chemother. 44(9), 2567-2568 (2000). 3.Collin, F.,Karkare, S. and Maxwell, A. Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl. Microbiol. Biotechnol. 92(3), 479-497 (2011). 4.Weigel, L.M.,Anderson, G.J. and Tenover, F.C. DNA gyrase and topoisomerase IV mutations associated with fluoroquinolone resistance in Proteus mirabilis. Antimicrob. Agents Chemother. 46(8), 2582-2587 (2002). 5.Grossman, R.F.,Hsueh, P.-R.,Gillespie, S.H., et al. Community-acquired pneumonia and tuberculosis: Differential diagnosis and the use of fluoroquinolones. Int. J. Infect. Dis. 18, 14-21 (2014). 6.Pranger, A.D.,Alffenaar, J.W.C. and Aarnoutse, R.E. Fluoroquinolones, the cornerstone of treatment of drug-resistant tuberculosis: A pharmacokinetic and pharmacodynamic approach. Curr. Pharm. Des. 17(27), 29002-29930 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 485.5 |
| 分子式 | C18H20FN5O4 • CH3SO3H |
| CAS号 | 210353-53-0 |
| 稳定性 | ≥ 2 years |
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