Danirixin
货号：
20980-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 20980-1mg |
| 描述 | Danirixin is a potent and selective non-peptide antagonist of chemokine receptor 2 (CXCR2) that inhibits IL-8 binding to CXCR2 with an IC50 value of 12.5 nM.1 Levels of IL-8 are increased in sputum of patients with chronic obstructive pulmonary disease (COPD).2 Formulations containing danirixin demonstrate dose-dependent inhibition of IL-8 binding to CXCR2 with no relevant adverse events in clinical trials and a Phase I trial in Japan is ongoing to determine the dosing regimen for Phase IIa trials in patients with COPD.1 |
| 别名 | GSK 1325756; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Miller, B.E.,Smart, K.,Mistry, S.K., et al. The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers. Eur. J. Drug Metab. Pharmacokinet. 39(3), 173-181 (2014).
2.Mukaida, N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am. J. Physiol. Lung Cell Mol. Physiol. 284(4), L566–L577 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.9 |
| 分子式 | C19H21ClFN3O4S |
| CAS号 | 954126-98-8 |
| 稳定性 | ≥ 2 years |
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