| 货号 | 20505-50mg |
| 描述 | (±)-Nornicotine is a metabolite of nicotine (Item No. 16535) that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 µM, respectively, when expressed in Xenopusoocytes.1 Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line.2 It is generally thought to be free from abuse potential, but it has been self-administered by rats.3,4 It can be detected in urine.5 |
| 别名 | DL-Nornicotine;(R,S)-Nornicotine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Papke, R.L.,Dwoskin, L.P. and Crooks, P.A. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: Relevance to nicotine dependence and drug discovery. J. Neurochem. 101(1), 160-167 (2007). 2.Gagat, M.,Grzanka, D.,Izdebska, M., et al. Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actin. Folia Histochem. Cytobiol. 51(3), 179-192 (2013). 3.Bardo, M.T.,Green, T.A.,Crooks, P.A., et al. Nornicotine is self-administered intravenously by rats. Psychopharmacology (Berl) 146(3), 290-296 (1999). 4.Hoffman, A.C. and Evans, S.E. Abuse potential of non-nicotine tobacco smoke components: Acetaldehyde, nornicotine, cotinine, and anabasine. Nicotine Tob. Res. 15(3), 622-632 (2013). 5.von Weymarn, L.B.,Thomson, N.M.,Donny, E.C., et al. Quantitation of the minor tobacco alkaloids nornicotine, anatabine, and anabasine in smokers urine by high throughput liquid chromatography-mass spectrometry. Chem. Res. Toxicol. 29(3), 390-397 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 148.2 |
| 分子式 | C9H12N2 |
| CAS号 | 5746-86-1 |
| 稳定性 | ≥ 2 years |
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