LY2603618
货号：
20351-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 20351-1mg |
| 描述 | LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents.1 It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation.2 LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of chemotherapeutic agents such as gemcitabine (Item No. 11690).3 |
| 别名 | IC-83;Rabusertib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.King, C.,Diaz, H.,Barnard, D., et al. Characterization and preclinical development of LY2603618: A selective and potent Chk1 inhibitor. Invest New Drugs 32(2), 213-226 (2014).
2.Wang, F.-Z.,Fei, H.-r.,Cui, Y.-J., et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 19(9), 1389-1398 (2014).
3.Barnard, D.,Diaz, H.B.,Burke, T., et al. LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models. Invest New Drugs 34(1), 49-60 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 436.3 |
| 分子式 | C18H22BrN5O3 |
| CAS号 | 911222-45-2 |
| 稳定性 | ≥ 2 years |
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