| 货号 | 20274-100mg |
| 描述 | Glycodeoxycholic acid (GDCA) is a conjugated secondary bile acid that is biosynthesized through the enzymatic addition of glycine to deoxycholic acid (Item Nos. 18231|20756). GDCA is one of twenty-five plasma metabolites found to significantly differ between asthmatic subjects and healthy controls.1 Serum bile acids are elevated in patients with acetaminophen-induced acute liver failure (AALF), and GDCA is significantly increased in non-surviving AALF patients compared with survivors.2 GDCA has been shown to induce a reversible, concentration-dependent reduction in myogenic tone in rats and to suppress the expression of cytochrome P450 isoform 7A1 in rabbits.3,4 |
| 别名 | GDCA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Comhair, S.A.A.,McDunn, J.,Bennett, C., et al. Metabolomic endotype of asthma. J. Immunol. 195(2), 643-650 (2015). 2.Woolbright, B.L.,McGill, M.R.,Staggs, V.S., et al. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicol. Sci. 142(2), 436-444 (2014). 3.Khurana, S.,Raina, H.,Pappas, V., et al. Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries. PLoS One 7(2), e32006 (2012). 4.Shang, Q.,Guo, G.L.,Honda, A., et al. Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits. Am. J. Physiol. Gastrointest. Liver Physiol. 307(4), G479-G486 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 449.6 |
| 分子式 | C26H43NO5 |
| CAS号 | 360-65-6 |
| 稳定性 | ≥ 2 years |
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