Nelarabine
货号：
20248-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 20248-1mg |
| 描述 | Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.1 Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.2,3 This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.1,3 Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.1 |
| 别名 | GW 506U78;Nelzarabine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Robak, T.,Korycka, A.,Lech-Maranda, E., et al. Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 14(3), 1183-1226 (2009).
2.Rodriguez, C.O., Jr.,Mitchell, B.S.,Ayres, M., et al. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res. 62(11), 3100-3105 (2002).
3.Rodriguez, C.O., Jr.,Stellrecht, C.M. and Gandhi, V. Mechanisms for T-cell selective cytotoxicity of arabinosylguanine. Blood 102(5), 1842-1848 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.3 |
| 分子式 | C11H15N5O5 |
| CAS号 | 121032-29-9 |
| 稳定性 | ≥ 2 years |
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