| 货号 | 20070-50mg |
| 描述 | Indacaterol is a selective β2 adrenoceptor agonist (pEC50 = 8.06) that has a very long duration of action (529 ± 99 min in isolated superfused guinea pig trachea).1 Long-acting β2-agonists (LABAs), including indacaterol, can evoke physiological effects like bronchodilation when used following a once-daily administration protocol.1,2 The efficacy of LABAs in respiratory diseases like asthma and chronic obstructive pulmonary disease is enhanced when used with inhaled steroids or long-acting muscarinic antagonists.3,4 |
| 别名 | QAB149; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Battram, C.,Charlton, S.J.,Cuenoud, B., et al. In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled b2 adrenoceptor agonist with a 24-h duration of action. J. Pharmacol. Exp. Ther. 317(2), 762-770 (2006). 2.Decramer, M.L.,Hanania, N.A.,Lötvall, J.O., et al. The safety of long-acting β2-agonists in the treatment of stable chronic obstructive pulmonary disease. Int.J.Chron.Obstruct.Pulmon.Dis. 8, 53-64 (2013). 3.Cazzola, M.,Calzetta, L.,Puxeddu, E., et al. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. Respir. Res. 17(1), (2016). 4.Cohen, J.S.,Miles, M.C.,Donohue, J.F., et al. Dual therapy strategies for COPD: The scientific rationale for LAMA + LABA. Int. J. Chron. Obstruct. Pulmon. Dis. 11, 785-797 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392.5 |
| 分子式 | C24H28N2O3 |
| CAS号 | 312753-06-3 |
| 稳定性 | ≥ 2 years |
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