| 货号 | 19997-5mg |
| 描述 | Loganin is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a substrate for cytochrome P450 72A1, also known as secologanin synthase, in the production of indolalkaloids.1 Loganin has been shown to have antioxidant, hepatoprotective, and neuroprotective effects in animal models.2,3,4 It can inhibit COX-1 enzyme activity (IC50 = 3.55 µM), suppress the formation of TNF-α, and diminish the production of nitric oxide.4 |
| 别名 | NSC 606403;7-hydroxy-6-desoxy Verbenalin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Irmler, S.,Schröder, G.,St-Pierre, B., et al. Indole alkaloid biosynthesis in Catharanthus roseus: New enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24(6), 797-804 (2000). 2.Kwon, S.-H.,Kim, J.-A.,Hong, S.-I., et al. Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK ½ MAPKs in SH-SY5Y cells. Neurochem Int. 58(4), 533-541 (2011). 3.Lee, N.-H.,Seo, C.-S.,Lee, H.-y., et al. Hepatoprotective and antioxidative activities of Cornus officinalis against acetaminophen-induced hepatotoxicity in mice. Evid. Based Complement. Med. 2012:804924, (2012). 4.Park, K.S.,Kim, B.H. and Chang, I.-M. Inhibitory potencies of several iridoids on cyclooxygenase-1, cyclooxygnase-2 enzymes activities, tumor necrosis factor-α and nitric oxide production in vitro. Evid Based Complement. Med. 7(1), 41-45 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.4 |
| 分子式 | C17H26O10 |
| CAS号 | 18524-94-2 |
| 稳定性 | ≥ 2 years |
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