| 货号 | 19914-1mg |
| 描述 | PD-1/PD-L1 inhibitor 1 is a compound that blocks the interaction of programmed cell death protein 1 (PD-1, CD279) with its ligand protein (PD-L1, CD274). In preliminary studies, PD-1/PD-L1 inhibitor 1 blocks this interaction with an IC50 value between 6 and 100 nM, as assessed by a homogenous time-resolved fluorescence binding assay.1 Antibodies that block PD-1/PD-L1 interaction reduce signaling between these co-inhibitory molecules and have shown promise as checkpoint immunomodulators in cancer clinical trials.2,3,4 |
| 别名 | Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chupak, L.S. and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015). 2.Antonia, S.J.,Vansteenkiste, J.F. and Moon, E. Immunotherapy: Beyond anti-PD-1 and anti-PD-L1 therapies. Am. Soc. Clin. Oncol. Educ. Book 35, e450-e458 (2016). 3.Farkona, S.,Diamandis, E.P. and Blasutig, I.M. Cancer immunotherapy: The beginning of the end of cancer? BMC Med. 14(1), 73 (2016). 4.Norde, W.J.,Hobo, W.,van der Voort, R., et al. Coinhibitory molecules in hematologic malignancies: Targets for therapeutic intervention. Blood 120(4), 728-736 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 475.6 |
| 分子式 | C29H33NO5 |
| CAS号 | 1675201-83-8 |
| 稳定性 | ≥ 2 years |
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