FIIN-2
货号：
19837-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19837-1mg |
| 描述 | FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.1 It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2.1 By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tan, L.,Wang, J.,Tanizaki, J., et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc. Natl. Acad. Sci. USA 111(45), E4869-E4877 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 634.7 |
| 分子式 | C35H38N8O4 |
| CAS号 | 1633044-56-0 |
| 稳定性 | ≥ 2 years |
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