E7046
货号：
19673-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 19673-5mg |
| 描述 | E7046 is a specific antagonist of the type 4 prostaglandin E2(PGE2) receptor EP4. It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.1 E7046 is being evaluated in cancer models and clinical trials, alone or in combination with other immunotherapeutic compounds.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bao, X.,Albu, D.,Huang, K.-C., et al. Combination of EP4 antagonist and checkpoint inhibitors promotes anti-tumor effector T cells in preclinical tumor models. J.Immunother.Cancer 3(suppl 2), (2015).
2.Albu, D.I.,Huang, K.-C.,Wu, J., et al. Preclinical immune antitumor activity of myeloid-targeting E7046 and treg depleting E7777. Cancer Immunol.Res. 4(1 Suppl), (2016).
3.Hong, D.S.,Kwak, E.L.,Guo, M., et al. Phase 1 study of E7046, an inhibitor of the PGE2 receptor EP-4, that targets immunosuppressive myeloid cells in the tumor microenvironment (NCT02540291). J.Clin.Oncol. 34, (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 483.4 |
| 分子式 | C22H18F5N3O4 |
| CAS号 | 1369489-71-3 |
| 稳定性 | ≥ 2 years |
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