NPS 1034
货号：
19627-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19627-1mg |
| 描述 | NPS 1034 is a dual inhibitor of the receptor tyrosine kinase activities of MET (IC50 = 48 nM) and AXL (IC50 = 10.3 nM), receptors for hepatocyte growth factor and vitamin K-dependent proteins, respectively.1 It synergistically inhibits cell proliferation when used in combination with gefitinib (Item No. 13166) or erlotinib (Item No. 10483) in NSCLC cells with acquired resistance to EGFR receptor tyrosine kinase inhibitors.1 NPS 1034 inhibits autophosphorylation of numerous constitutively active mutant forms of MET (IC50s<25 nM) and inhibits the invasion and migration of MET mutant-transfected cells.2 It also inhibits growth of MKN45 xenograft tumors in mice treated orally with 30 mg/kg NPS 1034 for 25 days.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rho, J.K.,Choi, Y.J.,Kim, S.Y., et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 74(1), 253-262 (2014).
2.Shin, J.-S.,Hong, S.-W.,Moon, J.-H., et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs 32(3), 389-399 (2014).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 551.6 |
| 分子式 | C31H23F2N5O3 |
| CAS号 | 1221713-92-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
