Podophyllotoxin
货号：
19575-100mg 基本售价：
406.0 元 规格：
100 mg
产品信息
概述| 货号 | 19575-100mg |
| 描述 | Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllumspecies.1,2 It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide (Item No. 12092), teniposide (Item No. 14425), and etopophos.1,2 |
| 别名 | NSC 24818;Podofilox;PPT; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xu, H.,Lv, M. and Tian, X. A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007. Current Medicinal Chemistry 16(3), 327-349 (2009).
2.Lau, W. and Sattely, E.S. Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone. Science 349(6253), 1224-1228 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 414.4 |
| 分子式 | C22H22O8 |
| CAS号 | 518-28-5 |
| 稳定性 | ≥ 2 years |
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