| 货号 | 19568-1mg |
| 描述 | Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity.1 It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis.2 Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines.3 Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mamoci, E.,Cavoski, I.,Simone, V., et al. Chemical composition and in vitro activity of plant extracts from Ferula communis and Dittrichia viscosa against postharvest fungi. Molecules 16(3), 2609-2625 (2011). 2.Monti, M.,Pinotti, M.,Appendino, G., et al. Characterization of anti-coagulant properties of prenylated coumarin ferulenol. Biochim.Biophys.Acta. 1770(10), 1437-1440 (2007). 3.Bocca, C.,Gabriel, L.,Bozzo, F., et al. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol. Planta Medica 68(12), 1135-1137 (2002). 4.Lahouel, M.,Zini, R.,Zellagui, A., et al. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochemical and Biophysical Research Communications 355(1), 252-257 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.5 |
| 分子式 | C24H30O3 |
| CAS号 | 6805-34-1 |
| 稳定性 | ≥ 2 years |
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