4β-hydroxy Cholesterol
货号：
19518-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19518-1mg |
| 描述 | 4β-hydroxy Cholesterol, a major oxysterol found in human circulation, is formed from cholesterol by cytochrome P450 (CYP)3A4 and CYP3A5. It has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.1 This metabolite has been suggested as a marker for CYP3A4/5 activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Maheux, C.R.,Alarcon, I.Q.,Copeland, C.R., et al. Identification of polymorphism in ethylone hydrochloride: Synthesis and characterization. Drug Test.Anal. 092015, (2015).
2.Dicfalusy, U.,Kanebratt, K.P.,Bredberg, E., et al. 4β-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. British Journal of Clinical Pharmacology 67(1), 38-43 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 17320-10-4 |
| 稳定性 | ≥ 2 years |
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