MI-136
货号：
19245-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19245-1mg |
| 描述 | MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM).1,2 By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription.3 At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Borkin, D.,Pollock, J.,Kempinska, K., et al. Property focused structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL). Journal of Medicinal Chemistry 59(3), 892-913 (2016).
2.Borkin, D.,He, S.,Miao, H., et al. Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell 27, 589-602 (2015).
3.Malik, R.,Khan, A.P.,Asangani, I.A., et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat. Med. 21(4), 344-352 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470.5 |
| 分子式 | C23H21F3N6S |
| CAS号 | 1628316-74-4 |
| 稳定性 | ≥ 2 years |
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