GSK269962
货号：
19180-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19180-1mg |
| 描述 | Two Rho-associated kinases (ROCKS), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively.1 It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.1 GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM).1 Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.1 |
| 别名 | GSK269962A;GSK269962B; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Doe, C.,Bentley, R.,Behm, D.J., et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. Journal of Pharmacology and Experimental Therapeutics 320(1), 89-98 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 570.6 |
| 分子式 | C29H30N8O5 |
| CAS号 | 850664-21-0 |
| 稳定性 | ≥ 2 years |
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