GNE-3511
货号：
19174-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19174-1mg |
| 描述 | GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK), also known as MAP3K12 (Ki = 500 pM).1 It also inhibits phosphorylated JNK (IC50 = 30 nM) and is highly selective for DLK over other MAP kinases (IC50 > 5,000 nM for MKK4 and MKK7), JNKs (IC50 = 129, 514, and 364 nM for JNK1, JNK2, and JNK3, respectively), and mixed lineage kinases (MLK; IC50 = 68, 767, and 602 nM for MLK1, MLK2, and MLK3, respectively). GNE-3511 protects primary neurons in an in vitro axon degeneration assay (IC50 = 107 nM). In an MPTP mouse model of Parkinson’s disease, a high dose of GNE-3511 (75 mg/kg) completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose (37.5 mg/kg) moderately reduces its expression. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Patel, S.,Cohen, F.,Dean, B.J., et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J. Med. Chem. 58(1), 401-418 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.5 |
| 分子式 | C23H26F2N6O |
| CAS号 | 1496581-76-0 |
| 稳定性 | ≥ 2 years |
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