CP 724,714
货号：
19172-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19172-1mg |
| 描述 | CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM.1 It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met.1 CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively.1 It also demonstrates antitumor activity in various human tumor xenograft models.1 However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jani, J.P.,Finn, R.S.,Campbell, M., et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Research 67(20), 9887-9893 (2007).
2.Feng, B.,Xu, J.J.,Bi, Y.A., et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicological Sciences 108(2), 492-500 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 469.5 |
| 分子式 | C27H27N5O3 |
| CAS号 | 383432-38-0 |
| 稳定性 | ≥ 2 years |
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