PF-4800567
货号：
19171-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19171-1mg |
| 描述 | PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.1 It blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells.1 PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walton, K.M.,Fisher, K.,Rubitski, D., et al. Selective inhibition of casein kinase 1ε minimally alters circadian clock period. Journal of Pharmacology and Experimental Therapeutics 330(2), 430-439 (2009).
2.Meng, Q.J.,Maywood, E.S.,Bechtold, D.A., et al. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proceedings of the National Academy of Sciences of the United States of America 107(34), 15240-15245 (2016).
3.Perez, D.I.,Gil, C. and Martinez, A. Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases. Medicinal Research Reviews 31(6), 924-954 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 359.8 |
| 分子式 | C17H18ClN5O2 |
| CAS号 | 1188296-52-7 |
| 稳定性 | ≥ 2 years |
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