CPI-360
货号：
19125-500ug 基本售价：
406.0 元 规格：
500 ug
产品信息
概述| 货号 | 19125-500ug |
| 描述 | CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.1 It decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines.1 Twice daily, subcutaneous administration of 200 mg/kg of CPI-360 reduced tumor growth of KARPAS-422 xenografts in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bradley, W.D.,Arora, S.,Busby, J., et al. EZH2 inhibitor efficacy in non-Hodgkin’s lymphoma does not require suppression of H3K27 monomethylation. Chemistry & Biology 21, 1-13 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 437.5 |
| 分子式 | C25H31N3O4 |
| CAS号 | 1802175-06-9 |
| 稳定性 | ≥ 2 years |
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