ONO-8130
货号：
19118-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19118-1mg |
| 描述 | ONO-8130 is an orally bioavailable antagonist of the prostaglandin E2(PGE2) receptor EP(Ki = 1.9 nM)1,2 It exerts a more than 1,000-fold selectivity for EP1 compared with other EP receptors.2 ONO-8130 suppresses pain associated with cyclophosphamide-induced cystitis in mice at 0.3-30 mg/kg.1 It also blocks PGE2-induced contraction and eliminates spontaneous tone of guinea pig trachea tested in tissue organ baths.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Miki, T.,Matsunami, M.,Nakamura, S., et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152(6), 1373-1381 (2011).
2.Säfholm, J.,Dahlén, S.E.,Delin, I., et al. PGE2 maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1 receptors and relaxant EP2 receptors. British Journal of Pharmacology 168, 794-806 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 500.6 |
| 分子式 | C25H28N2O5S2 |
| CAS号 | 459841-96-4 |
| 稳定性 | ≥ 2 years |
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