HJC0197
货号：
19092-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19092-1mg |
| 描述 | Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 µM for Epac2).1 It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 µM, but has no effect on cAMP-induced type I and II PKA activity at this concentration.1 Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 µM HJC0197 completely blocks Epac-mediated phosphorylation of Akt.1 HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, H.,Tsalkova, T.,Mei, F.C., et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorganic & Medicinal Chemistry Letters 22(12), 4038-4043 (2012).
2.Juhász, T.,Matta, C.,Somogyi, C., et al. Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures. Cell Signal. 26, 468-482 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.5 |
| 分子式 | C19H21N3OS |
| CAS号 | 1383539-73-8 |
| 稳定性 | ≥ 2 years |
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