CL 387,785
货号：
19081-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 19081-1mg |
| 描述 | Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.1 CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM).2 It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM).2 CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.2 |
| 别名 | EKB-785;EKI-785;WAY-EKI-785; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sausville, E.A.,Elsayed, Y.,Monga, M., et al. Signal transduction-directed cancer treatments. Annual Reviews of Pharmacology and Toxicology 43, 199-231 (2003).
2.Discafani, C.M.,Carroll, M.L.,Floyd, M.B., Jr., et al. Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785). Biochemical Pharmacology 57(8), 917-925 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 381.2 |
| 分子式 | C18H13BrN4O |
| CAS号 | 194423-06-8 |
| 稳定性 | ≥ 2 years |
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