| 货号 | 19074-500ug |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.4 At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.4 FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.4 |
| 别名 | Frizzled M1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 2.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 3.Reya, T. and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 4.Generoso, S.F.,Giustinano, M.,La Regina, G., et al. Pharmacological folding chaperones act as allosteric ligands of Frizzled4. Nature Chemical Biology 11, 280-286 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 360.4 |
| 分子式 | C21H16N2O2S |
| CAS号 | 1680196-54-6 |
| 稳定性 | ≥ 2 years |
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