GSK864
货号：
18762-500ug 基本售价：
406.0 元 规格：
500 ug
产品信息
概述| 货号 | 18762-500ug |
| 描述 | GSK864 is an allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1; IC50s = 9, 15, and 17 nM for IDH1 mutants R132C, R132H, and R132G, respectively).1 It is moderately selective for mutant IDH1 over wild-type IDH1 and IDH2 mutants/wild-type. GSK864 causes a dose-dependent reduction in 2-hydroxyglutarate and overcomes the block of differentiation in acute myeloid leukemia (AML) cells expressing mutant IDH1.1 It reduces the number of leukemic blasts in mice with AML xenografts.1 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Okoye-Okafor, U.C.,Bartholdy, B.,Cartier, J., et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nature Chemical Biology 11, 878-892 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 558.6 |
| 分子式 | C30H31FN6O4 |
| CAS号 | 1816331-66-4 |
| 稳定性 | ≥ 2 years |
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