| 货号 | 18625-5mg |
| 描述 | Betaxolol is a selective β1-adrenergic receptor antagonist (log KDs = -8.21, -7.38, and -5.97 for β1, β2, and β3, respectively).1 This beta-blocker has been used to reduce intraocular pressure in research models of ocular hypertension and glaucoma.2,3,4 It is also reported to act as a neuroprotective agent in animals, attenuating excitotoxicity or ischemia-induced damage to retinal ganglion cells.5 |
| 别名 | Kerlone;SL 75212; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 2.Pozarowska, D.,Pozarowski, P. and Darzynkiewicz, Z. Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells. Cytometry B Clin.Cytom. 78(2), 130-137 (2010). 3.Miao, Y.,Sun, Q.,Wen, Q., et al. Cytotoxic effects ofβolol on healthy corneal endothelial cells both in vitro and in vivo. Int.J.Ophthalmol. 7(1), 14-21 (2014). 4.Heijl, A.,Leske, M.C.,Hyman, L., et al. Intraocular pressure reduction with a fixed treatment protocol in the Early Manifest Glaucoma Trial. Acta.Ophthalmol. 89(8), 749-754 (2011). 5.Chidlow, G.,Melena, J. and Osborne, N.N. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical sunaptosomes by direct interaction with Na+ channels: Comparison with other β-adrenoceptor antagonists. British Journal of Pharmacology 130, 759-766 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 343.9 |
| 分子式 | C18H29NO3 • HCl |
| CAS号 | 63659-19-8 |
| 稳定性 | ≥ 2 years |
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