BMS-777607
货号：
18517-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18517-1mg |
| 描述 | BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.1 At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).1 In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.1,2 In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.1 |
| 别名 | BMS-817378; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sharma, S.,Zeng, J.Y.,Zhuang, C.M., et al. Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Molecular Cancer Therapeutics 12(5), 725-736 (2013).
2.Dai, Y. and Siemann, D.W. BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Molecular Cancer Therapeutics 9(6), 1554-1561 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 512.9 |
| 分子式 | C25H19ClF2N4O4 |
| CAS号 | 1025720-94-8 |
| 稳定性 | ≥ 2 years |
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