Ciprofibrate
货号：
18515-1g 基本售价：
406.0 元 规格：
1 g
产品信息
概述| 货号 | 18515-1g |
| 描述 | Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Ciprofibrate activates PPARα with an EC50 value of 20 µM and only marginally affects PPARγ (EC50 = >300 µM).1 It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia.1,2 Ciprofibrate reportedly stimulates cholesteryl ester transfer protein expression and improves the flow of cholesterol through the indirect reverse cholesterol transport system, preserving plasma HDL.3 |
| 别名 | (±)-Ciprofibrate;WIN 35,833; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Guerre-Millo, M.,Gervois, P.,Raspé, E., et al. Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity. The Journal of Biological Chemisty 275, 16638-16642 (2000).
2.Aguilar-Salinas, C.A.,Assis-Luores-Vale, A.,Stockins, B., et al. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: Greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study). Cardiovascular Diabetology 3(8), (2004).
3.Bighetti, E.J.B.,Patricio, P.R.,Casquero, A.C., et al. Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver. Lipids in Health and Disease 8(50), (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 289.2 |
| 分子式 | C13H14Cl2O3 |
| CAS号 | 52214-84-3 |
| 稳定性 | ≥ 2 years |
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