PF-562271 (besylate)
货号：
18499-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18499-1mg |
| 描述 | Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) are non-receptor tyrosine kinases that constitute the FAK subfamily and play a vital role in many oncogenic pathways.1 PF-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) that demonstrates 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases.2 PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Parsons, J.T.,Slack-Davis, J.,Tilghman, R., et al. Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention. Clinical Cancer Research 14(3), 627-632 (2008).
2.Roberts, W.G.,Ung, E.,Whalen, P., et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Research 68(6), 1935-1944 (2008).
3.Stokes, J.B.,Adair, S.J.,Slack-Davis, J.K., et al. Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Molecular Cancer Therapeutics 10(11), 2135-2145 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 665.7 |
| 分子式 | C21H20F3N7O3S • C6H6O3S |
| CAS号 | 939791-38-5 |
| 稳定性 | ≥ 2 years |
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