| 货号 | 18497-1mg |
| 描述 | S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes.1 It inhibits intracellular pH recovery in myocytes with a Ki value of 1.7 µM, with full inhibition occurring at ~30 µM.1 S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig.2 S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, F.F.T.,Villafuerte, F.C.,Swietach, P., et al. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart. British Journal of Pharmacology 153, 972-982 (2008). 2.Yamamoto, T.,Swietach, P.,Rossini, A., et al. Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig. Journal of Physiology 562.2, 455-475 (2005). 3.Kumar, S.,Flacke, J.P.,Kostin, S., et al. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovascular Research 89(2), 392-400 (2011). 4.Lauritzen, G.,Stock, C.M.,Lemarie, J., et al. The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Letters 317(2), 172-183 (2012). 5.Orlowski, A.,Vargas, L.A.,Aiello, E.A., et al. Elevated carbon dioxide upregulates NBCn1 Na+/HCO3- cotransporter in human embryonic kidney cells. American Journal of Physiology.Renal Physiology 305, F1765-F1774 (2013). 6.Giambelluca, M.S.,Ciancio, M.C.,Orlowski, A., et al. Characterization of the Na/HCO3- cotransport in human neutrophils. Cell Physiology and Biochemistry 33(4), 982-990 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 530 |
| 分子式 | C29H24ClN3O3S |
| CAS号 | 1019331-10-2 |
| 稳定性 | ≥ 2 years |
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