ASP3026
货号：
18491-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18491-1mg |
| 描述 | ASP3026 is an ATP-competitive, second-generation ALK inhibitor (IC50 = 3.5 nM) that also inhibits ROS (IC50 = 8.9 nM) and ACK (IC50 = 5.8 nM).1,2 It inhibits neuroblastoma-activating ALK mutants F1174L (IC50 = 10 nM) and R1275Q (IC50 = 5.4 nM) and demonstrates antitumor activity in xenograft mouse models.1,2 ASP3026 has been shown to overcome crizotinib (Item No. 12087) resistance in non-small cell lung cancer, and is currently being evaluated in clinical trials of patients with ALK-positive solid tumors.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mori, M.,Ueno, Y.,Konagai, S., et al. The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice. Molecular Cancer Therapeutics 13(2), 329-340 (2015).
2.Awad, M.M. and Shaw, A.T. ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond. Clin. Adv. Hematol. Oncol. 12(7), 429-439 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 580.7 |
| 分子式 | C29H40N8O3S |
| CAS号 | 1097917-15-1 |
| 稳定性 | ≥ 2 years |
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