Novobiocin (sodium salt)
货号：
18457-1g 基本售价：
406.0 元 规格：
1 g
产品信息
概述| 货号 | 18457-1g |
| 描述 | Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Novobiocin is a coumarin antibiotic, first isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase.1 Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit.1 In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA.2 It has also been shown to inhibit the chaperone activity of Hsp90.3 |
| 别名 | NSC 2382; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Collin, F.,Karkare, S. and Maxwell, A. Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl. Microbiol. Biotechnol. 92(3), 479-497 (2011).
2.Lockshon, D. and Morris, D.R. Positively supercoiled plasmid DNA is produced by treatment of Escherichia coli with DNA gyrase inhibitors. Nucleic Acids Research 11(10), 2999-3017 (1983).
3.Allan, R.K.,Mok, D.,Ward, B.K., et al. Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: Evidence that coumarin antibiotics disrupt Hsp90 dimerization. The Journal of Biological Chemisty 281(11), 7161-7171 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 634.6 |
| 分子式 | C31H35N2O11 • Na |
| CAS号 | 1476-53-5 |
| 稳定性 | ≥ 2 years |
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