AEE788
货号：
18416-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18416-1mg |
| 描述 | AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members.1 It can inhibit EGFR and VEGFR tyrosine kinases with IC50 values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively.1 AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells.1 It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.1 |
| 别名 | NVP-AEE788; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Traxler, P.,Allegrini, P.R.,Brandt, R., et al. AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Research 64(14), 4931-4941 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.6 |
| 分子式 | C27H32N6 |
| CAS号 | 497839-62-0 |
| 稳定性 | ≥ 2 years |
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