CVT-10216
货号：
18318-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18318-1mg |
| 描述 | Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the major oxidative pathway of alcohol metabolism. CVT-10216 is a reversible inhibitor of ALDH2 (IC50 = 29 nM) that demonstrates >40-fold selectivity for ALDH2 over the cytosolic isoform, ALDH1.1 CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.1 This compound has also been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety.1 The efficacy of CVT-10216 has also been examined in rodent models of drug addiction or binge eating of high-fat or high-sugar diets.2 |
| 别名 | GS-455534; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Overstreet, D.H.,Knappa, D.J.,Breese, G.R., et al. A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacology, Biochemistry, and Behavior 94(2), 255-261 (2009).
2.Bocarsly, M.E.,Hoebel, B.G.,Paredes, D., et al. GS 455534 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats. Behav.Pharmacol. 25(2), 147-157 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.5 |
| 分子式 | C24H19NO7S |
| CAS号 | 1005334-57-5 |
| 稳定性 | ≥ 2 years |
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