Carbenoxolone (sodium salt)
货号：
18240-1g 基本售价：
406.0 元 规格：
1 g
产品信息
概述| 货号 | 18240-1g |
| 描述 | Carbenoxolone is a derivative of β-glycyrrhetinic acid (Item No. 11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to β-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties.1 Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Item No. 10007815) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension.2 It is also reported to inhibit 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sircus, W. Carbenoxolone sodium. Gut 13(10), 816-824 (1972).
2.Quinkler, M. and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. Journal of Clinical Endocrinology and Metabolism 88(6), 2384-2392 (2003).
3.Hellmich, H.L.,Rojo, D.R.,Micci, M.A., et al. Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury. PLoS One 8(1), e53230 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 614.7 |
| 分子式 | C34H48O7 • 2Na |
| CAS号 | 7421-40-1 |
| 稳定性 | ≥ 2 years |
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