Digitoxigenin
货号：
18229-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 18229-5mg |
| 描述 | Digitoxigenin is a cardenolide and aglycone constituent of digitoxin, an extract from the foxglove plant, D. purpurea. It elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ATPasevia binding at the digitalis receptor site with nanomolar potency.1,2 Digitoxigenin is highly cytotoxic, inhibiting Na+/K+ ATPase-dependent protein synthesis, and has been examined for use as an antitumor compound.3 |
| 别名 | Cerberigenin;(+)-Digitoxigenin;Echujetin;Evonogenin;NSC 407806;Thevetigenin;Δ20:22-3,14,21-Trihydroxynorcholenic acid lactone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balzan, S.,DUrso, G.,Ghione, S., et al. Selective inhibition of human erythrocyte Na+/K+ ATPase by cardiac glycosides and by a mammalian digitalis like factor. Life Sciences 67(16), 1921-1928 (2000).
2.Katz, A.,Lifshitz, Y.,Bab-Dinitz, E., et al. Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase. The Journal of Biological Chemisty 285(25), 19582-19592 (2010).
3.Perne, A.,Muellner, M.K.,Steinrueck, M., et al. Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. PLoS One 4(12), 1-9 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.5 |
| 分子式 | C23H34O4 |
| CAS号 | 143-62-4 |
| 稳定性 | ≥ 2 years |
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