BI-6727
货号：
18193-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18193-1mg |
| 描述 | Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling.1 BI-6727 is a dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC50s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis.2 It inhibits proliferation of multiple cancer cell lines with EC50 values ranging from 11-37 nM and prevents the growth of various human carcinoma xenografts in mice.2 BI-6727 was found to reverse ABC-efflux transporter-mediated multidrug resistance activity through its inhibition of the transport activity of ABCB1 and ABCG2, thus promoting mitotic arrest in resistant cancer cells.3 |
| 别名 | Volasertib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schöffski, P. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist 14(6), 559-570 (2009).
2.Rudolph, D.,Steegmaier, M.,Hoffmann, M., et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clinical Cancer Research 15(9), 3094-3102 (2009).
3.To, K.K.W.,Poon, D.C.,Chen, X.G., et al. Volasertib (BI 6727), a novel polo-like kinase inhibitor reverses ABCB1 and ABCG2-mediated multidrug resistance in cancer cells. J.Cancer Ther.Res. 2(13), 1-10 (2015).
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| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 618.8 |
| 分子式 | C34H50N8O3 |
| CAS号 | 755038-65-4 |
| 稳定性 | ≥ 2 years |
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