| 货号 | 18155-50mg |
| 描述 | 5-Chloro-2-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine.1 Like 5-bromo-2’-deoxyuridine (Item No. 15580) and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues.2,3 CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations.4,5 The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.1,6 |
| 别名 | Chlorodeoxyuridine;CldU; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Patra, A.,Harp, J.,Pallan, P.S., et al. Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs. Nucleic Acids Research 41(4), 2689-2697 (2012). 2.Yuan, C.J.,Quiocho, J.M.D.,Kim, A., et al. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacology, Biochemistry, and Behavior 100(1), 98-108 (2011). 3.Anda, S.,Boye, E. and Grallert, B. Cell-cycle analyses using thymidine analogues in fission yeast. PLoS One 9(2), 1-9 (2014). 4.Llorens-Martín, M.,Tejeda, G.S. and Trejo, J.L. Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: A sueal birthdating analysis. PLoS One 5(8), 1-15 (2010). 5.Tuttle, A.H.,Rankin, M.M.,Teta, M., et al. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J.Vis.Exp. 7(46), 2-5 (2010). 6.Fox, L.M.,Mekras, J.A.,Bagwell, C.B., et al. Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity. Antimicrobial Agents and Chemotherapy 22(3), 431-441 (1982). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 262.6 |
| 分子式 | C9H11ClN2O5 |
| CAS号 | 50-90-8 |
| 稳定性 | ≥ 2 years |
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