| 货号 | 18127-1mg |
| 描述 | KPT-330 is a selective inhibitor of nuclear export proteins. It covalently binds to Cys528 in the nuclear export signal-binding groove of CRM1 (exportin 1), inhibiting its nuclear export function.1,2 It demonstrates potent anticancer activity, inducing apoptosis in various leukemia and multiple myeloma cell lines (IC50s = 34-203 nM) and mouse models.3,4 KPT-330 has been examined in several phase I and phase II clinical trials in both solid and hematological malignancies.4 |
| 别名 | Selinexor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Etchin, J.,Montero, J.,Berezovskaya, A., et al. Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia 30(1), 190-199 (2016). 2.Etchin, J.,Sun, Q.,Kentsis, A., et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia 27(1), 66-74 (2013). 3.Etchin, J.,Sanda, T.,Mansour, M.R., et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. British Journal of Haematology 161(1), 117-127 (2013). 4.Das, A.,Wei, G.,Parikh, K., et al. Selective inhibitors of nuclear export (SINE) in hematological malignancies. Exp.Hermatol.Oncol. 4(7), (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 443.3 |
| 分子式 | C17H11F6N7O |
| CAS号 | 1393477-72-9 |
| 稳定性 | ≥ 2 years |
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