2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide
货号：
18085-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 18085-1mg |
| 描述 | 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is a sulfide-like inhibitor of phosphodiesterase 7 (PDE7; IC50 = 2.1 µM).1 It is selective for PDE7A, producing only 10-11% inhibition of PDE3A, PDE4D, and PDE4B at 10 µM.1 It also has no antioxidant activity or inhibitory activity against a panel of protein kinases.1 Sulfide-like PDE7 inhibitors derived from 2-acetamidophenyl 5-chloro-2-nitrophenyl sulfide have cytoprotective and anti-inflammatory effects on SH-SY5Y neuroblastoma cells without action in a surrogate emesis mouse model.1 |
| 别名 | 2-(5-chloro-2-nitrophenylthio)-Acetanilide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.García, A.M.,Brea, J.,Morales-Garcia, J.A., et al. Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. Journal of Medicinal Chemistry 57(20), 8590-8607 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.8 |
| 分子式 | C14H11ClN2O3S |
| CAS号 | 107522-19-0 |
| 稳定性 | ≥ 2 years |
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